Journal of Pathology and Translational Medicine

Brief Case Report

Inflammatory Myofibroblastic Tumor of the Thyroid Gland: A Brief Case Report: Hye Jeong Kim, Jong In Na, Ji Shin Lee, Dong Hyeok Cho, Jin Seong Cho; Korean J Pathol. 2014;48(4):319-322. Published online August 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.319

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Inflammatory myofibroblastic tumor of the thyroid gland
Yiyang Zhang, Jia Liu
Frontiers in Endocrinology.2023;[Epub] CrossRef
ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto’s thyroiditis: report of a rare case and a literature review
Cheng-fang Li, Xing-long Wu, Jin-jing Wang, Kai Wang, Su-yuan Zhang, Jia-jia Huang, Han-zhong Hu, Hong Zheng
Diagnostic Pathology.2020;[Epub] CrossRef
Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity
Pallavi A. Patil, Ronald A. DeLellis
Archives of Pathology & Laboratory Medicine.2018; 142(8): 998. CrossRef

Original Article

Evaluation of Protein Expression in Housekeeping Genes across Multiple Tissues in Rats: Hye Jeong Kim, Jong In Na, Byung Woo Min, Joo Young Na, Kyung Hwa Lee, Jae Hyuk Lee, Young Jik Lee, Hyung Seok Kim, Jong Tae Park; Korean J Pathol. 2014;48(3):193-200. Published online June 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.193

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Abstract PDF

Background

Housekeeping genes, which show constant protein expression patterns between different tissue types, are very important in molecular biological studies as an internal control for protein research.

Methods

The protein expression profiles of seven housekeeping genes (HPRT1, PPIA, GYS1, TBP, YWHAZ, GAPDH and ACTB) in various rat tissues (cerebrum, cerebellum, cardiac ventricle and atrium, psoas muscle, femoral muscle, liver, spleen, kidney, and aorta) were analyzed by Western blot and compared by coefficient of variation (CV).

Results

HPRT1 was stably expressed (CV≤10%) in six tissues (cerebrum, cerebellum, ventricle, femoral muscle, spleen, and kidney), PPIA was stably expressed in five tissues (cerebrum, cerebellum, ventricle, spleen and kidney), YWHAZ was stably expressed in three tissues (cerebrum, cerebellum, and kidney), and GAPDH was stably expressed in four tissues (cerebrum, ventricle, psoas muscle, and kidney). In comparison, GYS1, TBP, and ACTB were found to have CV values over 10% in all tissues. Of the seven genes examined, four (HPRT1, PPIA, YWHAZ, and GAPDH) were found to be stably expressed across multiple organs, with low CV values (≤10%).

Conclusions

These results will provide fundamental information regarding internal controls for protein expression studies and can be used for analysis of postmortem protein degradation patterns in forensic medicine.

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